![]() ![]() ![]() All isolates had the same speA allotype, speA2. All the M1 strains studied had the emm1.0 allele and the same streptococcal pyrogenic exotoxin (Spe) genotype, speA + speB + speC speF + speG + speH smeZ + ssa. All patients were infected with M1T1 strains and, based on clinical criteria, were classified as severe ( n = 21) and nonsevere ( n = 14) invasive GAS infection cases. The relatedness of group A streptococcal (GAS) strains isolated from 35 Canadian patients with invasive disease of different severity was investigated by a variety of molecular methods.
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